![]() Medications with a low therapeutic index require close monitoring of blood levels since the toxic amount of the drug can be reached too easily. One example of this is the antibiotic amoxicillin. A wide range of drug concentrations would be okay. Medications with a higher therapeutic index are safer because there is less likelihood of reaching the toxicity amount, so there is no need for close monitoring of blood levels. ![]() The high end of the therapeutic index range is the maximum amount of that drug that should be in the body (beyond which is toxic). The low end of the therapeutic index range is the minimum amount of a drug needed in the body to be effective (minimum effective concentration). The therapeutic index for a medication is a range of doses at which the medication is effective without adverse toxic effects.
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